Force generation by molecular-motor powered microtubulebundles; implications for neuronal polarization and growth

Force generation by molecular-motor powered microtubulebundles; implications for neuronal polarization and growth

The heavily cross-linked microtubule (MT) bundles found in neuronalprocesses play a central role in the initiation, growth andmaturation of axons and dendrites; however, a quantitativeunderstanding of their mechanical function is still lacking. We heredeveloped computer simulations to investigate th...

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Bibliographic Details
Main Authors: Maximilian eJakobs, Kristian eFranze, Assaf eZemel
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Microtubules
Axon outgrowth
Neuronal polarization
molecular motors
force generation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00441/full

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