Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells

Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells

A series of 3,5-bis(benzylidene)-1-dichloroacetyl-4-piperidones <b>1a</b>–<b>l</b> was evaluated against Ca9-22, HSC-2, HSC-3, and HSC-4 squamous cell carcinomas. Virtually all of the compounds displayed potent cytotoxicity, with 83% of the CC<sub>50</sub> values...

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Bibliographic Details
Main Authors: Mohammad Hossain, Praveen K. Roayapalley, Hiroshi Sakagami, Keitaro Satoh, Kenjiro Bandow, Umashankar Das, Jonathan R. Dimmock
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Medicines
Subjects:
unsaturated ketones
cytotoxicity
dichloroacetic acid
tumor-selective toxicity
structure-activity relationships
Online Access:https://www.mdpi.com/2305-6320/9/6/35

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https://www.mdpi.com/2305-6320/9/6/35

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