Prospective Assessment of No Evidence of Disease Activity-4 Status in Early Disease Stages of Multiple Sclerosis in Routine Clinical Practice

Prospective Assessment of No Evidence of Disease Activity-4 Status in Early Disease Stages of Multiple Sclerosis in Routine Clinical Practice

Background: In relapsing-remitting multiple sclerosis, no evidence of disease activity-3 (NEDA-3) is defined as no relapses, no disability progression and no MRI activity. NEDA-4 status is defined as meeting all NEDA-3 criteria plus having an annualized brain volume loss (a-BVL) of ≤0.4%. Prospectiv...

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Bibliographic Details
Main Authors: Carlos Guevara, Cristian Garrido, Melissa Martinez, Gonzalo A. Farias, Patricia Orellana, Wendy Soruco, Pablo Alarcón, Violeta Diaz, Carlos Silva, Matthew J. Kempton, Gareth Barker, José de Grazia
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neurology
Subjects:
relapsing/remitting
quantitative MRI
outcome measurement (NEDA-4)
multiple sclerosis
brain atrophy
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00788/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.00788/full

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