Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism

Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism

Abstract Background Drug metabolism is crucial to attaining the therapeutic index of any drug. The metabolism and elimination of the drugs are governed mainly by P-glycoprotein (P-gp) and Cytochrome P450 (CYP). Paracetamol is mostly used as analgesic and antipyretic agent. The metabolism of paraceta...

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Bibliographic Details
Main Authors: Ravindra Babu Pingili, Sridhar Vemulapalli, Manideep V. V. N. Gadamsetty, Divya Presingu, Ruthvik Katuri, Vijayalakshmi Rachamsetty, Naveen Babu Kilaru
Format: Article
Language:English
Published: SpringerOpen 2023-04-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
CYP2E1
N-Acetyl-p-benzoquinoneimine
Chlorzoxazone
Paracetamol
Hepatotoxicity
Nephrotoxicity
Online Access:https://doi.org/10.1186/s43094-023-00484-2

Internet

https://doi.org/10.1186/s43094-023-00484-2

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