Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

Abstract α-Synuclein (αSyn) aggregation in Lewy bodies and neurites defines both familial and ‘sporadic’ Parkinson’s disease. We previously identified α-helically folded αSyn tetramers, in addition to the long-known unfolded monomers, in normal cells. PD-causing αSyn mutations decrease the tetramer:...

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Bibliographic Details
Main Authors: Luis Fonseca-Ornelas, Jonathan M. S. Stricker, Stephanie Soriano-Cruz, Beatrice Weykopf, Ulf Dettmer, Christina R. Muratore, Clemens R. Scherzer, Dennis J. Selkoe
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00380-1

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https://doi.org/10.1038/s41531-022-00380-1

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