Cap-Specific m<sup>6</sup>Am Methyltransferase PCIF1/CAPAM Regulates mRNA Stability of <i>RAB23</i> and <i>CNOT6</i> through the m<sup>6</sup>A Methyltransferase Activity

Cap-Specific m<sup>6</sup>Am Methyltransferase PCIF1/CAPAM Regulates mRNA Stability of <i>RAB23</i> and <i>CNOT6</i> through the m<sup>6</sup>A Methyltransferase Activity

Chemical modifications of cellular RNAs play key roles in gene expression and host defense. The cap-adjacent <i>N</i><sup>6</sup>,2′-<i>O</i>-dimethyladenosine (m<sup>6</sup>Am) is a prevalent modification of vertebrate and viral mRNAs and is catalyzed...

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Bibliographic Details
Main Authors: Ai Sugita, Ryoya Kano, Hiroyasu Ishiguro, Natsuki Yanagisawa, Soichiro Kuruma, Shotaro Wani, Aki Tanaka, Yoshiaki Tabuchi, Yoshiaki Ohkuma, Yutaka Hirose
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Cells
Subjects:
gene expression
mRNA modifications
mRNA stability
transcription
mRNA cap
m<sup>6</sup>A
Online Access:https://www.mdpi.com/2073-4409/13/20/1689

Internet

https://www.mdpi.com/2073-4409/13/20/1689

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