Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection.

Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection.

Aspergillus fumigatus forms ubiquitous airborne conidia that humans inhale on a daily basis. Although respiratory fungal infection activates the adaptor proteins CARD9 and MyD88 via C-type lectin, Toll-like, and interleukin-1 family receptor signals, defining the temporal and spatial pattern of MyD8...

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Bibliographic Details
Main Authors: Anupam Jhingran, Shinji Kasahara, Kelly M Shepardson, Beth A Fallert Junecko, Lena J Heung, Debra K Kumasaka, Sue E Knoblaugh, Xin Lin, Barbara I Kazmierczak, Todd A Reinhart, Robert A Cramer, Tobias M Hohl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4306481?pdf=render

Internet

http://europepmc.org/articles/PMC4306481?pdf=render

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