The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

Activation of the main DNA interstrand crosslink repair pathway in higher eukaryotes requires mono-ubiquitination of FANCI and FANCD2 by FANCL, the E3 ligase subunit of the Fanconi anemia core complex. FANCI and FANCD2 form a stable complex; however, the molecular basis of their ubiquitination is il...

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Bibliographic Details
Main Authors: Paolo Swuec, Ludovic Renault, Aaron Borg, Fenil Shah, Vincent J. Murphy, Sylvie van Twest, Ambrosius P. Snijders, Andrew J. Deans, Alessandro Costa
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
interstrand crosslink
Fanconi anemia
ubiquitin ligase
DNA repair
cryo-electron microscopy
mono-ubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716315546

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http://www.sciencedirect.com/science/article/pii/S2211124716315546

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