Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis

Tertiary and Quaternary Structure Organization in GMP Synthetases: Implications for Catalysis

Glutamine amidotransferases, enzymes that transfer nitrogen from Gln to various cellular metabolites, are modular, with the amidotransferase (GATase) domain hydrolyzing Gln, generating ammonia and the acceptor domain catalyzing the addition of nitrogen onto its cognate substrate. GMP synthetase (GMP...

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Bibliographic Details
Main Authors: Lionel Ballut, Sébastien Violot, Frédéric Galisson, Isabelle R. Gonçalves, Juliette Martin, Santosh Shivakumaraswamy, Loïc Carrique, Hemalatha Balaram, Nushin Aghajari
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomolecules
Subjects:
glutamine amidotransferase
GMP synthetase
<i>Plasmodium falciparum</i>
conformational changes
ammonia channel
allosteric regulation
Online Access:https://www.mdpi.com/2218-273X/12/7/871

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https://www.mdpi.com/2218-273X/12/7/871

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