A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs

A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs

AMP-activated protein kinase (AMPK), a master regulator of cellular metabolism, is a potential target for type 2 diabetes. Although extensive in vitro studies have revealed the complex regulation of AMPK, much remains unknown about the regulation in vivo. We therefore developed transgenic mice expre...

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Bibliographic Details
Main Authors: Yumi Konagaya, Kenta Terai, Yusuke Hirao, Kanako Takakura, Masamichi Imajo, Yuji Kamioka, Norio Sasaoka, Akira Kakizuka, Kenta Sumiyama, Tomoichiro Asano, Michiyuki Matsuda
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
fluorescence resonance energy transfer
FRET
AMP-activated protein kinase
AMPK
liver kinase B1
LKB1
peptidyl-prolyl cis/trans isomerase NIMA-interacting 1
Pin1
cell metabolism
live imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717315930

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http://www.sciencedirect.com/science/article/pii/S2211124717315930

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