Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

Src-family kinases (SFKs) are non-receptor protein-tyrosine kinases involved in a variety of signaling pathways in virtually every cell type. The SFKs share a common negative regulatory mechanism that involves intramolecular interactions of the SH3 domain with the PPII helix formed by the SH2-kinase...

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Bibliographic Details
Main Authors: Jamie A Moroco, Jodi K Craigo, Roxana E Iacob, Thomas E Wales, John R Engen, Thomas E Smithgall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4140816?pdf=render

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http://europepmc.org/articles/PMC4140816?pdf=render

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