The role of inab in axon morphology of an identified zebrafish motoneuron.

The ability of an animal to move and to interact with its environment requires that motoneurons correctly innervate specific muscles. Although many genes that regulate motoneuron development have been identified, our understanding of motor axon branching remains incomplete. We used transcriptional e...

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Main Authors: Liesl Van Ryswyk, Levi Simonson, Judith S Eisen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3922942?pdf=render
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author Liesl Van Ryswyk
Levi Simonson
Judith S Eisen
author_facet Liesl Van Ryswyk
Levi Simonson
Judith S Eisen
author_sort Liesl Van Ryswyk
collection DOAJ
description The ability of an animal to move and to interact with its environment requires that motoneurons correctly innervate specific muscles. Although many genes that regulate motoneuron development have been identified, our understanding of motor axon branching remains incomplete. We used transcriptional expression profiling to identify potential candidate genes involved in development of zebrafish identified motoneurons. Here we focus on inab, an intermediate filament encoding gene dynamically expressed in a subset of motoneurons as well as in an identified interneuron. We show that inab is necessary for proper axon morphology of a specific motoneuron subtype.
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spelling doaj.art-e150aa9d8b564283b4e7b6abee4559142022-12-21T23:48:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8863110.1371/journal.pone.0088631The role of inab in axon morphology of an identified zebrafish motoneuron.Liesl Van RyswykLevi SimonsonJudith S EisenThe ability of an animal to move and to interact with its environment requires that motoneurons correctly innervate specific muscles. Although many genes that regulate motoneuron development have been identified, our understanding of motor axon branching remains incomplete. We used transcriptional expression profiling to identify potential candidate genes involved in development of zebrafish identified motoneurons. Here we focus on inab, an intermediate filament encoding gene dynamically expressed in a subset of motoneurons as well as in an identified interneuron. We show that inab is necessary for proper axon morphology of a specific motoneuron subtype.http://europepmc.org/articles/PMC3922942?pdf=render
spellingShingle Liesl Van Ryswyk
Levi Simonson
Judith S Eisen
The role of inab in axon morphology of an identified zebrafish motoneuron.
PLoS ONE
title The role of inab in axon morphology of an identified zebrafish motoneuron.
title_full The role of inab in axon morphology of an identified zebrafish motoneuron.
title_fullStr The role of inab in axon morphology of an identified zebrafish motoneuron.
title_full_unstemmed The role of inab in axon morphology of an identified zebrafish motoneuron.
title_short The role of inab in axon morphology of an identified zebrafish motoneuron.
title_sort role of inab in axon morphology of an identified zebrafish motoneuron
url http://europepmc.org/articles/PMC3922942?pdf=render
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