Revealing how phenytoin triggers liver damage and the potential protective effects of Balanites Aegyptiaca fruit extracts: Exploring Nrf2/MAPK/ Beclin-1 signaling pathways

Revealing how phenytoin triggers liver damage and the potential protective effects of Balanites Aegyptiaca fruit extracts: Exploring Nrf2/MAPK/ Beclin-1 signaling pathways

Phenytoin-induced liver injury (PHT ILII) is a serious condition that may necessitate discontinuation of the drug. This study investigates the mechanisms of PHT ILII and evaluates the protective effects of Balanites Aegyptiaca (BA) fruit extracts on the liver. We focus on the Nrf2/MAPK/NF-κB/Beclin-...

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Bibliographic Details
Main Authors: Shaimaa M. Azzam, Marwa Refaat Abdel khalek, Amina A.S. Abdel Rahman, Amany Abdelhameid Osman, Heba Mohammed Refat M. Selim, Asmaa Fady Sharif, Yomna Ahmad El-khattib, Sameh Rabea, Sahar K. Ali, Alshaymaa Darwish
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Phenytoin
Phenytoin Idiosyncratic Induced Liver Injury
Balanites Aegyptiaca
Nrf2/MAPK signals
Antioxidant
Anti-inflammatory
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223010569

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http://www.sciencedirect.com/science/article/pii/S0753332223010569

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