Malignant peripheral nerve sheath tumor (MPNST) and MPNST-like entities are defined by a specific DNA methylation profile in pediatric and juvenile population

Malignant peripheral nerve sheath tumor (MPNST) and MPNST-like entities are defined by a specific DNA methylation profile in pediatric and juvenile population

Abstract Background Malignant peripheral nerve sheath tumors (MPNSTs) account for 3–10% of pediatric sarcomas, 50% of which occur in neurofibromatosis type 1 (NF1). Sporadic MPNSTs diagnosis may be challenging due to the absence of specific markers, apart from immunohistochemical H3K27me3 loss. DNA...

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Bibliographic Details
Main Authors: Sara Patrizi, Evelina Miele, Lorenza Falcone, Silvia Vallese, Sabrina Rossi, Sabina Barresi, Isabella Giovannoni, Lucia Pedace, Claudia Nardini, Ilaria Masier, Luana Abballe, Antonella Cacchione, Ida Russo, Angela Di Giannatale, Valentina Di Ruscio, Claudia Maria Salgado, Angela Mastronuzzi, Andrea Ciolfi, Marco Tartaglia, Giuseppe Maria Milano, Franco Locatelli, Rita Alaggio
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Clinical Epigenetics
Subjects:
Malignant peripheral nerve sheath tumors
DNA methylation
Sarcoma classifier
H3K27 trimethylation
Online Access:https://doi.org/10.1186/s13148-023-01621-7

Internet

https://doi.org/10.1186/s13148-023-01621-7

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