Pseudoislet Aggregation of Pancreatic β-Cells Improves Glucose Stimulated Insulin Secretion by Altering Glucose Metabolism and Increasing ATP Production

Pseudoislet Aggregation of Pancreatic β-Cells Improves Glucose Stimulated Insulin Secretion by Altering Glucose Metabolism and Increasing ATP Production

Appropriate glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells is an essential component of blood glucose homeostasis. Configuration of β-cells as 3D pseudoislets (PI) improves the GSIS response compared to 2D monolayer (ML) culture. The aim of this study was to determine the underlyi...

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Bibliographic Details
Main Authors: Deborah Cornell, Satomi Miwa, Merilin Georgiou, Scott James Anderson, Minna Honkanen-Scott, James A. M. Shaw, Catherine Arden
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
pancreatic β-cells
islets
pseudoislets
metabolism
connexin 36
glycolysis
Online Access:https://www.mdpi.com/2073-4409/11/15/2330

Internet

https://www.mdpi.com/2073-4409/11/15/2330

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