BacPE: a versatile prime-editing platform in bacteria by inhibiting DNA exonucleases

BacPE: a versatile prime-editing platform in bacteria by inhibiting DNA exonucleases

Abstract Prime editing allows precise installation of any single base substitution and small insertions and deletions without requiring homologous recombination or double-strand DNA breaks in eukaryotic cells. However, the applications in bacteria are hindered and the underlying mechanisms that impe...

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Bibliographic Details
Main Authors: Hongyuan Zhang, Jiacheng Ma, Zhaowei Wu, Xiaoyang Chen, Yangyang Qian, Weizhong Chen, Zhipeng Wang, Ya Zhang, Huanhu Zhu, Xingxu Huang, Quanjiang Ji
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45114-4

Internet

https://doi.org/10.1038/s41467-024-45114-4

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