Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

In this work, Louros et al. uncover a rule book for interactions of amyloids with other proteins. This grammar was shown to promote cellular spreading of tau aggregates in cells, but can also be harvested to develop structure-based aggregation blockers.

Bibliographic Details
Main Authors: Nikolaos Louros, Meine Ramakers, Emiel Michiels, Katerina Konstantoulea, Chiara Morelli, Teresa Garcia, Nele Moonen, Sam D’Haeyer, Vera Goossens, Dietmar Rudolf Thal, Dominique Audenaert, Frederic Rousseau, Joost Schymkowitz
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28955-9

Internet

https://doi.org/10.1038/s41467-022-28955-9

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