Retinal Development and Pathophysiology in Kcnj13 Knockout Mice

Retinal Development and Pathophysiology in Kcnj13 Knockout Mice

Purpose: We constructed and characterized knockout and conditional knockout mice for KCNJ13, encoding the inwardly rectifying K+ channel of the Kir superfamily Kir7.1, mutations in which cause both Snowflake Vitreoretinal Degeneration (SVD) and Retinitis pigmentosa (RP) to further elucidate the path...

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Main Authors: Xiaodong Jiao, Zhiwei Ma, Jingqi Lei, Pinghu Liu, Xiaoyu Cai, Pawan K. Shahi, Chi-Chao Chan, Robert Fariss, Bikash R. Pattnaik, Lijin Dong, J. Fielding Hejtmancik
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
retina
retinal dystrophy
snowflake vitreoretinal dystrophy
kcnj13/kir7.1
retinal degeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.810020/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.810020/full

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