Antigen discrimination by T cells relies on size-constrained microvillar contact

Antigen discrimination by T cells relies on size-constrained microvillar contact

T cells can use TCR on microvilli to interact with peptide-MHC (pMHC) complexes on antigen presenting cells. Here the authors characterise how T cells use microvilli to interrogate reconstituted membranes for pMHC complexes and how this is regulated by a balance between glycoproteins/glycocalyces th...

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Bibliographic Details
Main Authors: Edward Jenkins, Markus Körbel, Caitlin O’Brien-Ball, James McColl, Kevin Y. Chen, Mateusz Kotowski, Jane Humphrey, Anna H. Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F. Lee, Simon J. Davis, David Klenerman
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36855-9

Internet

https://doi.org/10.1038/s41467-023-36855-9

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