Comparative Thrombin Generation in Animal Plasma: Sensitivity to Human Factor XIa and Tissue Factor

Comparative Thrombin Generation in Animal Plasma: Sensitivity to Human Factor XIa and Tissue Factor

Preclinical evaluation of drugs in animals helps researchers to select potentially informative clinical laboratory markers for human trials. To assess the utility of animal thrombin generation (TG) assay, we studied the sensitivity of animal plasmas to triggers of TG, human Tissue Factor (TF), and A...

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Bibliographic Details
Main Authors: Yideng Liang, Ivan Tarandovskiy, Stepan S. Surov, Mikhail V. Ovanesov
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
thrombin generation
fibrin clot formation
animal model
tissue factor
activated factor XI
assay sensitivity
Online Access:https://www.mdpi.com/1422-0067/24/16/12920

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https://www.mdpi.com/1422-0067/24/16/12920

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