N-glycosylation is required for secretion and enzymatic activity of human hyaluronidase1

N-glycosylation is required for secretion and enzymatic activity of human hyaluronidase1

Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn99, Asn216, and Asn350. In this report, we show the functional significance of N-glycosylation on HYAL1 functions. Using mass spectrometry, we demonstrated that HYAL1...

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Bibliographic Details
Main Authors: Yuki Goto, Yuki Niwa, Takehiro Suzuki, Shiho Uematsu, Naoshi Dohmae, Siro Simizu
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Hyaluronidase1
N-glycosylation
Enzymatic activity
Secretion
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000564

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http://www.sciencedirect.com/science/article/pii/S2211546314000564

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