Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression

Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression

Abstract Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m6A) is the most abundant reversible methylation modification in mRNA contributing to tumorigenesis. However, the crucial rol...

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Bibliographic Details
Main Authors: Yaya Qiao, Meng Su, Huifang Zhao, Huanle Liu, Chenxi Wang, Xintong Dai, Lingling Liu, Guangju Liu, Huanran Sun, Mingming Sun, Jiyan Wang, Zhen Li, Jun Fan, Quan Zhang, Chunshen Li, Fangmin Situ, Jun Xue, Zhenghu Jia, Chunze Zhang, Shuai Zhang, Changliang Shan
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer (CRC)
N6-methyladenosine (m6A)
Ferroptosis
Fat mass and obesity-associated protein (FTO)
Solute carrier family 7 member 11 (SLC7A11)
Glutathione peroxidase 4 (GPX4)
Online Access:https://doi.org/10.1186/s13046-024-03032-9

Internet

https://doi.org/10.1186/s13046-024-03032-9

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