Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate that pharmacological inhibition of brain DYRK1A is able to correct recognition memory deficits in three DS mouse models with...

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Bibliographic Details
Main Authors: Thu Lan Nguyen, Arnaud Duchon, Antigoni Manousopoulou, Nadège Loaëc, Benoît Villiers, Guillaume Pani, Meltem Karatas, Anna E. Mechling, Laura-Adela Harsan, Emmanuelle Limanton, Jean-Pierre Bazureau, François Carreaux, Spiros D. Garbis, Laurent Meijer, Yann Herault
Format: Article
Language:English
Published: The Company of Biologists 2018-09-01
Series:Disease Models & Mechanisms
Subjects:
DYRK1A
Kinase inhibitor
Leucettine
Down syndrome
Synapsin
Online Access:http://dmm.biologists.org/content/11/9/dmm035634

Internet

http://dmm.biologists.org/content/11/9/dmm035634

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