The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer.

The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer.

The definitive characterization of common cancer stem cell (CSCs) subpopulations in breast cancer subtypes with distinct genotypic and phenotypic features remains an ongoing challenge. In this study, we have used a non-biased genome wide screening approach to identify transcriptional networks that m...

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Bibliographic Details
Main Authors: Claire A Walsh, Nina Akrap, Elena Garre, Ylva Magnusson, Hannah Harrison, Daniel Andersson, Emma Jonasson, Svanheidur Rafnsdottir, Hani Choudhry, Francesca Buffa, Jiannis Ragoussis, Anders Ståhlberg, Adrian Harris, Göran Landberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0236187

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https://doi.org/10.1371/journal.pone.0236187

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