Trimethylamine N-oxide impairs β-cell function and glucose tolerance

Trimethylamine N-oxide impairs β-cell function and glucose tolerance

Abstract β-Cell dysfunction and β-cell loss are hallmarks of type 2 diabetes (T2D). Here, we found that trimethylamine N-oxide (TMAO) at a similar concentration to that found in diabetes could directly decrease glucose-stimulated insulin secretion (GSIS) in MIN6 cells and primary islets from mice or...

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Podrobná bibliografie
Hlavní autoři: Lijuan Kong, Qijin Zhao, Xiaojing Jiang, Jinping Hu, Qian Jiang, Li Sheng, Xiaohong Peng, Shusen Wang, Yibing Chen, Yanjun Wan, Shaocong Hou, Xingfeng Liu, Chunxiao Ma, Yan Li, Li Quan, Liangyi Chen, Bing Cui, Pingping Li
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2024-03-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-024-46829-0

Internet

https://doi.org/10.1038/s41467-024-46829-0

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