A cheminformatics and network pharmacology approach to elucidate the mechanism of action of Mycobacterium tuberculosis γ-carbonic anhydrase inhibitors

A cheminformatics and network pharmacology approach to elucidate the mechanism of action of Mycobacterium tuberculosis γ-carbonic anhydrase inhibitors

BackgroundMycobacterium tuberculosis (Mtb) carbonic anhydrases (CAs) are critical enzymes that regulate pH by converting CO2 to HCO3−, essential for Mtb’s survival in acidic environments. Inhibiting γ-CAs presents a potential target for novel antituberculosis drugs with unique mechanisms of action.O...

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Bibliographic Details
Main Authors: Ajay Manaithiya, Ratul Bhowmik, Kunal Bhattacharya, Rajarshi Ray, Sagar Singh Shyamal, Fabrizio Carta, Claudiu T. Supuran, Seppo Parkkila, Ashok Aspatwar
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Pharmacology
Subjects:
Mycobacterium tuberculosis
γ-CAs
virtual screening
system biology
inflammatory responses
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1457012/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1457012/full

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