Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population

Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population

Summary: Natural human knockouts of genes associated with desirable outcomes, such as PCSK9 with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and treatments. Rare loss-of-function variants are more likely to be found in the homozygous state in consanguineous populatio...

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Bibliographic Details
Main Authors: Aziz Belkadi, Gaurav Thareja, Fatemeh Abbaszadeh, Ramin Badii, Eric Fauman, Omar M.E. Albagha, Karsten Suhre
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cell Genomics
Subjects:
human gene knockouts
metabolomics
proteomics
whole-genome sequencing
consanguineous population
drug target validation, drug target identification
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X22001719

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http://www.sciencedirect.com/science/article/pii/S2666979X22001719

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