High-resolution DNA methylation screening of the major histocompatibility complex in multiple sclerosis

High-resolution DNA methylation screening of the major histocompatibility complex in multiple sclerosis

BackgroundThe HLA-DRB1 gene in the major histocompatibility complex (MHC) region in chromosome 6p21 is the strongest genetic factor identified as influencing multiple sclerosis (MS) susceptibility. DNA methylation changes associated with MS have been consistently detected at the MHC region. However,...

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Bibliographic Details
Main Authors: Qin Ma, Danillo G. Augusto, Gonzalo Montero-Martin, Stacy J. Caillier, Kazutoyo Osoegawa, Bruce A. C. Cree, Stephen L. Hauser, Alessandro Didonna, Jill A. Hollenbach, Paul J. Norman, Marcelo Fernandez-Vina, Jorge R. Oksenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Neurology
Subjects:
DNA methylation
major histocompatibility complex
multiple sclerosis
differentially methylated regions
DNA methylation quantitative trait loci
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1326738/full

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https://www.frontiersin.org/articles/10.3389/fneur.2023.1326738/full

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