SOX9 Knockdown-Mediated FOXO3 Downregulation Confers Neuroprotection Against Ischemic Brain Injury

SOX9 Knockdown-Mediated FOXO3 Downregulation Confers Neuroprotection Against Ischemic Brain Injury

BackgroundEvidence exists uncovering that SRY-box transcription factor 9 (SOX9) plays a role in ischemic brain injury (IBI). Thus, the current study was conducted to elucidate the specific role of SOX9 and the mechanism by which SOX9 influenced IBI.MethodsThe IBI-associated regulatory factors were s...

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Bibliographic Details
Main Authors: Yiming Deng, Gaoting Ma, Feng Gao, Xuan Sun, Lian Liu, Dapeng Mo, Ning Ma, Ligang Song, Xiaochuan Huo, Hongwei He, Zhongrong Miao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ischemic brain injury
SRY-box transcription factor 9
forkhead box O3
transcription of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2
IκB kinase α
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.555175/full

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https://www.frontiersin.org/articles/10.3389/fcell.2020.555175/full

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