Cell division drives DNA methylation loss in late-replicating domains in primary human cells

DNA methylation loss has been observed in aging tissues and cancers for decades. Researchers from Van Andel Institute have now provided experimental evidence that this process is directly driven by cell division.

Bibliographic Details
Main Authors: Jamie L. Endicott, Paula A. Nolte, Hui Shen, Peter W. Laird
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34268-8