Identifying potential inhibitors of phosphatidylinositol 4,5-bisphosphate 3-kinase: Molecular dynamic insights into the interaction and inhibitory mechanism

Identifying potential inhibitors of phosphatidylinositol 4,5-bisphosphate 3-kinase: Molecular dynamic insights into the interaction and inhibitory mechanism

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) plays a crucial role in signaling pathways and has emerged as an attractive target for anticancer therapy. Developing small-molecule inhibitors targeting PIK3CA has emerged as a promising therapeutic strategy. Here, we e...

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Bibliographic Details
Main Authors: Taj Mohammad, Afzal Hussain, Mohamed F. Alajmi, Saba Hasan, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Chemical Physics Impact
Subjects:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha
Phytoconstituents
Apollinine
Isoglycyrol
Virtual screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022424000021

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http://www.sciencedirect.com/science/article/pii/S2667022424000021

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