Sildenafil ameliorates leptin resistance and normalizes lipid handling in the hypothalamic and adipose tissues of testosterone-exposed pregnant rats

Sildenafil ameliorates leptin resistance and normalizes lipid handling in the hypothalamic and adipose tissues of testosterone-exposed pregnant rats

Leptin and hypothalamic-adipose lipid handling are relevant in determining the shift of metabolic activities. There are scanty findings connecting glucose dysregulation as a result of hyperandrogenism during gestation to hypothalamic-adipose axis and leptin resistance. Sildenafil has recently gained...

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Bibliographic Details
Main Authors: Emmanuel Damilare Areola, Isaiah Woru Sabinari, Taofeek Olumayowa Usman, Faith Ifeoluwa Abayomi, Onyeka Onyezia, Bisola Onaolapo, Phebe Oluwaseun Adetokunbo, Olympus Oyewole Adebanjo, Funmilayo Rebecca Oladipupo, Lawrence Aderemi Olatunji
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Heliyon
Subjects:
Hypothalamus
Adipose tissue
Leptin resistance
PDE5 inhibitor
Lipid handling
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021016777

Internet

http://www.sciencedirect.com/science/article/pii/S2405844021016777

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