Organocatalyzed Michael Addition to Nitroalkenes via Masked Acetaldehyde

Organocatalyzed Michael Addition to Nitroalkenes via Masked Acetaldehyde

A novel and safe reaction protocol for the enantioselective enamine-catalysed addition of acetaldehyde to nitroalkenes is presented; this protocol makes use of a safe acetaldehyde precursor to access important intermediates to Active Pharmaceutical Ingredients (APIs), and allows the use of fewer equ...

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Bibliographic Details
Main Authors: Giuliana Giorgianni, Valeria Nori, Andrea Baschieri, Laura Palombi, Armando Carlone
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Catalysts
Subjects:
acetaldehyde
asymmetric catalysis
Michael addition
organocatalysis
pregabalin
Online Access:https://www.mdpi.com/2073-4344/10/11/1296

Internet

https://www.mdpi.com/2073-4344/10/11/1296

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