Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant
Mycophenolate mofetil (MMF) is an immunosuppressive agent, the gastrointestinal side effects of which include abdominal pain, diarrhoea, and vomiting. MMF may also cause symptomatic colitis, although it is a rare condition. We present herein the case of a boy with chronic kidney disease, lasting sin...
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Format: | Article |
Language: | English |
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Termedia Publishing House
2022-10-01
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Series: | Pediatria Polska |
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Online Access: | https://www.termedia.pl/Mycophenolate-mofetil-related-colitis-in-a-paediatric-patient-after-kidney-transplant,127,47965,1,1.html |
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author | Natalia Oleksik Monika Głowinkowska Maria Szczepańska Katarzyna Bąk-Drabik Wioletta Jarmużek |
author_facet | Natalia Oleksik Monika Głowinkowska Maria Szczepańska Katarzyna Bąk-Drabik Wioletta Jarmużek |
author_sort | Natalia Oleksik |
collection | DOAJ |
description | Mycophenolate mofetil (MMF) is an immunosuppressive agent, the gastrointestinal side effects of which include abdominal pain, diarrhoea, and vomiting. MMF may also cause symptomatic colitis, although it is a rare condition. We present herein the case of a boy with chronic kidney disease, lasting since the neonatal period, and caused by WT1 gene mutation. The patient developed colitis during an immunosuppressive therapy applied after a kidney transplant. Histopathology of intestinal biopsy specimens revealed features of MMF-related colitis. A modification of the immunosuppressive treatment and the implementation of a nutritional programme to the patient resulted in the disappearance of clinical signs and helped in a gradual body weight gain. |
first_indexed | 2024-04-24T11:28:13Z |
format | Article |
id | doaj.art-e19620e53ac14d9dba426f6e26274403 |
institution | Directory Open Access Journal |
issn | 0031-3939 2300-8660 |
language | English |
last_indexed | 2024-04-24T11:28:13Z |
publishDate | 2022-10-01 |
publisher | Termedia Publishing House |
record_format | Article |
series | Pediatria Polska |
spelling | doaj.art-e19620e53ac14d9dba426f6e262744032024-04-10T12:43:52ZengTermedia Publishing HousePediatria Polska0031-39392300-86602022-10-0197326026310.5114/polp.2022.12012247965Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplantNatalia OleksikMonika GłowinkowskaMaria SzczepańskaKatarzyna Bąk-DrabikWioletta JarmużekMycophenolate mofetil (MMF) is an immunosuppressive agent, the gastrointestinal side effects of which include abdominal pain, diarrhoea, and vomiting. MMF may also cause symptomatic colitis, although it is a rare condition. We present herein the case of a boy with chronic kidney disease, lasting since the neonatal period, and caused by WT1 gene mutation. The patient developed colitis during an immunosuppressive therapy applied after a kidney transplant. Histopathology of intestinal biopsy specimens revealed features of MMF-related colitis. A modification of the immunosuppressive treatment and the implementation of a nutritional programme to the patient resulted in the disappearance of clinical signs and helped in a gradual body weight gain.https://www.termedia.pl/Mycophenolate-mofetil-related-colitis-in-a-paediatric-patient-after-kidney-transplant,127,47965,1,1.htmlchildren mycophenolate mofetil kidney transplant colitis |
spellingShingle | Natalia Oleksik Monika Głowinkowska Maria Szczepańska Katarzyna Bąk-Drabik Wioletta Jarmużek Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant Pediatria Polska children mycophenolate mofetil kidney transplant colitis |
title | Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant |
title_full | Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant |
title_fullStr | Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant |
title_full_unstemmed | Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant |
title_short | Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant |
title_sort | mycophenolate mofetil related colitis in a paediatric patient after kidney transplant |
topic | children mycophenolate mofetil kidney transplant colitis |
url | https://www.termedia.pl/Mycophenolate-mofetil-related-colitis-in-a-paediatric-patient-after-kidney-transplant,127,47965,1,1.html |
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