Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant

Mycophenolate mofetil (MMF) is an immunosuppressive agent, the gastrointestinal side effects of which include abdominal pain, diarrhoea, and vomiting. MMF may also cause symptomatic colitis, although it is a rare condition. We present herein the case of a boy with chronic kidney disease, lasting sin...

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Main Authors: Natalia Oleksik, Monika Głowinkowska, Maria Szczepańska, Katarzyna Bąk-Drabik, Wioletta Jarmużek
Format: Article
Language:English
Published: Termedia Publishing House 2022-10-01
Series:Pediatria Polska
Subjects:
Online Access:https://www.termedia.pl/Mycophenolate-mofetil-related-colitis-in-a-paediatric-patient-after-kidney-transplant,127,47965,1,1.html
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author Natalia Oleksik
Monika Głowinkowska
Maria Szczepańska
Katarzyna Bąk-Drabik
Wioletta Jarmużek
author_facet Natalia Oleksik
Monika Głowinkowska
Maria Szczepańska
Katarzyna Bąk-Drabik
Wioletta Jarmużek
author_sort Natalia Oleksik
collection DOAJ
description Mycophenolate mofetil (MMF) is an immunosuppressive agent, the gastrointestinal side effects of which include abdominal pain, diarrhoea, and vomiting. MMF may also cause symptomatic colitis, although it is a rare condition. We present herein the case of a boy with chronic kidney disease, lasting since the neonatal period, and caused by WT1 gene mutation. The patient developed colitis during an immunosuppressive therapy applied after a kidney transplant. Histopathology of intestinal biopsy specimens revealed features of MMF-related colitis. A modification of the immunosuppressive treatment and the implementation of a nutritional programme to the patient resulted in the disappearance of clinical signs and helped in a gradual body weight gain.
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spelling doaj.art-e19620e53ac14d9dba426f6e262744032024-04-10T12:43:52ZengTermedia Publishing HousePediatria Polska0031-39392300-86602022-10-0197326026310.5114/polp.2022.12012247965Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplantNatalia OleksikMonika GłowinkowskaMaria SzczepańskaKatarzyna Bąk-DrabikWioletta JarmużekMycophenolate mofetil (MMF) is an immunosuppressive agent, the gastrointestinal side effects of which include abdominal pain, diarrhoea, and vomiting. MMF may also cause symptomatic colitis, although it is a rare condition. We present herein the case of a boy with chronic kidney disease, lasting since the neonatal period, and caused by WT1 gene mutation. The patient developed colitis during an immunosuppressive therapy applied after a kidney transplant. Histopathology of intestinal biopsy specimens revealed features of MMF-related colitis. A modification of the immunosuppressive treatment and the implementation of a nutritional programme to the patient resulted in the disappearance of clinical signs and helped in a gradual body weight gain.https://www.termedia.pl/Mycophenolate-mofetil-related-colitis-in-a-paediatric-patient-after-kidney-transplant,127,47965,1,1.htmlchildren mycophenolate mofetil kidney transplant colitis
spellingShingle Natalia Oleksik
Monika Głowinkowska
Maria Szczepańska
Katarzyna Bąk-Drabik
Wioletta Jarmużek
Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant
Pediatria Polska
children
mycophenolate mofetil
kidney transplant
colitis
title Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant
title_full Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant
title_fullStr Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant
title_full_unstemmed Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant
title_short Mycophenolate mofetil-related colitis in a paediatric patient after kidney transplant
title_sort mycophenolate mofetil related colitis in a paediatric patient after kidney transplant
topic children
mycophenolate mofetil
kidney transplant
colitis
url https://www.termedia.pl/Mycophenolate-mofetil-related-colitis-in-a-paediatric-patient-after-kidney-transplant,127,47965,1,1.html
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