Dibutyl phthalate (DBP) promotes Epithelial-Mesenchymal Transition (EMT) to aggravate liver fibrosis into cirrhosis and portal hypertension (PHT) via ROS/TGF-β1/Snail-1 signalling pathway in adult rats

Dibutyl phthalate (DBP) promotes Epithelial-Mesenchymal Transition (EMT) to aggravate liver fibrosis into cirrhosis and portal hypertension (PHT) via ROS/TGF-β1/Snail-1 signalling pathway in adult rats

Objective: The primary objective of this study was to investigate the toxicological impact of Dibutyl phthalate (DBP) on the process of liver fibrosis transitioning into cirrhosis and the subsequent development of portal hypertension (PHT) through the mechanism of epithelial-mesenchymal transition (...

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Bibliographic Details
Main Authors: Min Chen, Guang-Bo Wu, Shan Hua, Lei Zheng, Qiang Fan, Meng Luo
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Dibutyl phthalate
Cirrhosis
Portal hypertension
Epithelial-Mesenchymal Transition
Animal model
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324001994

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http://www.sciencedirect.com/science/article/pii/S0147651324001994

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