SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes

SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes

ABSTRACT Human papillomaviruses induce a host of anogenital cancers, as well as oropharyngeal cancer (HPV+OPC); human papillomavirus 16 (HPV16) is causative in around 90% of HPV+OPC cases. Using telomerase reverse transcriptase (TERT) immortalized foreskin keratinocytes (N/Tert-1), we have identifie...

Full description

Bibliographic Details
Main Authors: Claire D. James, Apurva T. Prabhakar, Raymonde Otoa, Michael R. Evans, Xu Wang, Molly L. Bristol, Kun Zhang, Renfeng Li, Iain M. Morgan
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mSphere
Subjects:
SAMHD1
differentiation
host-pathogen interactions
life cycle
papillomavirus
viral replication
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00448-19

Internet

https://journals.asm.org/doi/10.1128/mSphere.00448-19

Similar Items