Spirocyclopiperazinium salt compound DXL-A-24 improves visceral sensation and gut microbiota in a rat model of irritable bowel syndrome

Spirocyclopiperazinium salt compound DXL-A-24 improves visceral sensation and gut microbiota in a rat model of irritable bowel syndrome

Irritable bowel syndrome (IBS) is characterized by visceral pain, impaired intestinal barrier and a disorder of the microbiota. DXL-A-24 has analgesic and anti-inflammatory effects by inhibiting neuropeptides and inflammatory factors. In this study, we used chronic unpredictable mild stress (CUMS) i...

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Bibliographic Details
Main Authors: Yan Xu, Ru Yao, Wenxue Zhao, Jianguo Zhu, Jingchun Yao, Guimin Zhang, Dongguang Liu
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
Irritable bowel syndrome
Microbiota
Visceral hypersensitivity
Gut barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023037519

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http://www.sciencedirect.com/science/article/pii/S2405844023037519

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