A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study
Background and objectivesInsulin resistance (IR) is closely related to the decline or deficiency of testosterone in males. Triglyceride glucose-body mass (TyG-BMI) is considered to be a novel indicator of IR. We conducted this analysis to investigate the association between TyG-BMI and male testoste...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1187212/full |
| _version_ | 1797807682146533376 |
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| author | Shenghao Wu Yanhong Wu Lizi Fang Junzhao Zhao Yaoyao Cai Weiting Xia |
| author_facet | Shenghao Wu Yanhong Wu Lizi Fang Junzhao Zhao Yaoyao Cai Weiting Xia |
| author_sort | Shenghao Wu |
| collection | DOAJ |
| description | Background and objectivesInsulin resistance (IR) is closely related to the decline or deficiency of testosterone in males. Triglyceride glucose-body mass (TyG-BMI) is considered to be a novel indicator of IR. We conducted this analysis to investigate the association between TyG-BMI and male testosterone, and to explore whether its ability to predict testosterone deficiency is superior to HOMA-IR and TyG.MethodsThis was a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES, 2011–2016). The TyG-BMI index was calculated from serum triglyceride, fasting plasma glucose and BMI. The association of TyG-BMI with male testosterone was estimated by weighted multivariable regression.ResultsWe included 3394 participants for the final analysis. After adjusting for confounders, TyG-BMI was found to show an independent negative association with testosterone (β=-1.12, 95%CI: -1.50, -0.75, P<0.0001). Multivariate-adjusted beta also showed testosterone levels were significantly lower in the two highest TyG-BMI group (Q3, Q4) compared to the lowest group (Q1). Similar results were seen in all of the subgroup populations by stratified analysis (all P-interaction >0.05). Furthermore, ROC curve analysis indicated that the area under the curve of TyG-BMI index (0.73, 95% CI: 0.71, 0.75) was larger than that of HOMA-IR index (0.71, 95% CI: 0.69, 0.73) and TyG index (0.66, 95% CI: 0.64, 0.68).ConclusionOur result suggested a negative association between TyG-BMI index and testosterone in adult males. The predictability of the TyG-BMI index for testosterone deficiency is better than that of HOMA-IR index and TyG index. |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T06:26:18Z |
| publishDate | 2023-06-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-e1a275317be24fdfbc65a1152ae2e86a2023-06-09T09:21:07ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-06-011410.3389/fendo.2023.11872121187212A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional studyShenghao Wu0Yanhong Wu1Lizi Fang2Junzhao Zhao3Yaoyao Cai4Weiting Xia5Reproductive Medicine Center, Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaReproductive Medicine Center, Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaReproductive Medicine Center, Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaReproductive Medicine Center, Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Obstetrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaBackground and objectivesInsulin resistance (IR) is closely related to the decline or deficiency of testosterone in males. Triglyceride glucose-body mass (TyG-BMI) is considered to be a novel indicator of IR. We conducted this analysis to investigate the association between TyG-BMI and male testosterone, and to explore whether its ability to predict testosterone deficiency is superior to HOMA-IR and TyG.MethodsThis was a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES, 2011–2016). The TyG-BMI index was calculated from serum triglyceride, fasting plasma glucose and BMI. The association of TyG-BMI with male testosterone was estimated by weighted multivariable regression.ResultsWe included 3394 participants for the final analysis. After adjusting for confounders, TyG-BMI was found to show an independent negative association with testosterone (β=-1.12, 95%CI: -1.50, -0.75, P<0.0001). Multivariate-adjusted beta also showed testosterone levels were significantly lower in the two highest TyG-BMI group (Q3, Q4) compared to the lowest group (Q1). Similar results were seen in all of the subgroup populations by stratified analysis (all P-interaction >0.05). Furthermore, ROC curve analysis indicated that the area under the curve of TyG-BMI index (0.73, 95% CI: 0.71, 0.75) was larger than that of HOMA-IR index (0.71, 95% CI: 0.69, 0.73) and TyG index (0.66, 95% CI: 0.64, 0.68).ConclusionOur result suggested a negative association between TyG-BMI index and testosterone in adult males. The predictability of the TyG-BMI index for testosterone deficiency is better than that of HOMA-IR index and TyG index.https://www.frontiersin.org/articles/10.3389/fendo.2023.1187212/fulltestosteronetriglyceride glucose-body mass indexInsulin resistanceNHANESTyG-BMI |
| spellingShingle | Shenghao Wu Yanhong Wu Lizi Fang Junzhao Zhao Yaoyao Cai Weiting Xia A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study Frontiers in Endocrinology testosterone triglyceride glucose-body mass index Insulin resistance NHANES TyG-BMI |
| title | A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study |
| title_full | A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study |
| title_fullStr | A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study |
| title_full_unstemmed | A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study |
| title_short | A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study |
| title_sort | negative association between triglyceride glucose body mass index and testosterone in adult males a cross sectional study |
| topic | testosterone triglyceride glucose-body mass index Insulin resistance NHANES TyG-BMI |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1187212/full |
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