ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNβ/λ expression and promotes ZIKV persistence

ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNβ/λ expression and promotes ZIKV persistence

ABSTRACT Zika virus (ZIKV) is a mosquito-borne Flavivirus that persistently infects patients; enters protected brain, placental, and testicular compartments; is sexually transmitted; and causes fetal microcephaly in utero. ZIKV persistently infects human brain microvascular endothelial cells (hBMECs...

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Bibliographic Details
Main Authors: William R. Schutt, Jonas N. Conde, Megan C. Mladinich, Grace E. Himmler, Erich R. Mackow
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
Zika virus
tristetraprolin
endothelial cells
Sertoli cells
interferon regulation
persistence
Online Access:https://journals.asm.org/doi/10.1128/mbio.01742-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01742-23

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