INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay

INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay

Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral compounds that prevent the insertion of a DNA copy of the viral genome into the host genome by targeting the viral enzyme integrase (IN). Dolutegravir (DTG) is a leading INSTI that is given, usually in combination with nucle...

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Bibliographic Details
Main Authors: Steven J. Smith, Andrea Ferris, Xuezhi Zhao, Gary Pauly, Joel P. Schneider, Terrence R. Burke, Stephen H. Hughes
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
inhibition
integration
resistance
efficacy
infectivity
Online Access:https://www.mdpi.com/1999-4915/13/12/2501

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https://www.mdpi.com/1999-4915/13/12/2501

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