Homogenization of Amorphous Solid Dispersions Prepared by Electrospinning in Low-Dose Tablet Formulation

Homogenization of Amorphous Solid Dispersions Prepared by Electrospinning in Low-Dose Tablet Formulation

Low-dose tablet formulations were produced with excellent homogeneity based on drug-loaded electrospun fibers prepared by single-needle as well as scaled-up electrospinning (SNES and HSES). Carvedilol (CAR), a BCS II class compound, served as the model drug while poly (vinylpyrrolidone-co-vinyl acet...

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Bibliographic Details
Main Authors: Gergő Fülöp, Attila Balogh, Balazs Farkas, Attila Farkas, Bence Szabó, Balázs Démuth, Enikő Borbás, Zsombor Kristóf Nagy, György Marosi
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Pharmaceutics
Subjects:
carvedilol
poly (vinylpyrrolidone-co-vinyl acetate)
high-speed electrospinning
high-shear mixing
homogenization
Raman mapping
sieve analysis
Online Access:http://www.mdpi.com/1999-4923/10/3/114

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http://www.mdpi.com/1999-4923/10/3/114

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