Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway

Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway

Hepatocellular carcinoma (HCC) has a high mortality rate worldwide, and treatment is very limited due to its high recurrence and low diagnosis rate, and therefore there is an increasing need to develop more effective drugs to treat HCC. Coptisine is one of the isoquinoline alkaloids, and it has vari...

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Bibliographic Details
Main Authors: So Young Kim, Hyun Hwangbo, Hyesook Lee, Cheol Park, Gi-Young Kim, Sung-Kwon Moon, Seok Joong Yun, Wun-Jae Kim, Jaehun Cheong, Yung Hyun Choi
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
coptisine
DNA damage
Hep3B cells
c-Jun N-terminal kinase
reactive oxygen species
Online Access:https://www.mdpi.com/1422-0067/21/15/5502

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https://www.mdpi.com/1422-0067/21/15/5502

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