Highly variable timing renders immunotherapy efficacy and toxicity impractical biomarkers of one another in clinical practice

Highly variable timing renders immunotherapy efficacy and toxicity impractical biomarkers of one another in clinical practice

BackgroundA useful clinical biomarker requires not only association but also a consistent temporal relationship. For instance, chemotherapy-induced neutropenia and epidermal growth-factor inhibitor-related acneiform rash both occur within weeks of treatment initiation, thereby providing information...

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Bibliographic Details
Main Authors: Mitchell S. von Itzstein, Yuqiu Yang, Yiqing Wang, David Hsiehchen, Thomas Y. Sheffield, Farjana Fattah, Vinita Popat, Murtaza Ahmed, Jade Homsi, Jonathan E. Dowell, Sawsan Rashdan, Jay Lohrey, Hans J. Hammers, Randall S. Hughes, Tao Wang, Yang Xie, David E. Gerber
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
efficacy
immune checkpoint inhibitor (ICI)
immune-related adverse event (irAE)
immunotherapy
monitoring
toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1351739/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1351739/full

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