Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antitumoral Drugs Induced-Cytotoxicity in Human Colon Adenocarcinoma Cells

Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antitumoral Drugs Induced-Cytotoxicity in Human Colon Adenocarcinoma Cells

Diabetes and cancer are common, chronic, and potentially fatal diseases that frequently co-exist. Observational studies clearly indicate that the risk of several types of cancer is increased in diabetic patients and a number of cancer types have shown a higher mortality rate in patients with hypergl...

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Bibliographic Details
Main Authors: Loredana Bergandi, Eleonora Mungo, Rosa Morone, Ornella Bosco, Barbara Rolando, Sophie Doublier
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
hyperglycemia
chemoresistance
doxorubicin
5-fluorouracil
cytotoxicity
cell damage
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00866/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00866/full

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