Stanniocalcin‐2 inhibits skeletal muscle growth and is upregulated in functional overload‐induced hypertrophy

Stanniocalcin‐2 inhibits skeletal muscle growth and is upregulated in functional overload‐induced hypertrophy

Abstract Aims Stanniocalcin‐2 (STC2) has recently been implicated in human muscle mass variability by genetic analysis. Biochemically, STC2 inhibits the proteolytic activity of the metalloproteinase PAPP‐A, which promotes muscle growth by upregulating the insulin‐like growth factor (IGF) axis. The a...

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Bibliographic Details
Main Authors: Arimantas Lionikas, Ana I. Hernandez Cordero, Audrius Kilikevicius, Andrew M. Carroll, Guy S. Bewick, Lutz Bunger, Aivaras Ratkevicius, Lora K. Heisler, Mette Harboe, Claus Oxvig
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Physiological Reports
Subjects:
IGF
resistance training
skeletal muscle
STC2
Online Access:https://doi.org/10.14814/phy2.15793

Internet

https://doi.org/10.14814/phy2.15793

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