Chk1 and the Host Cell DNA Damage Response as a Potential Antiviral Target in BK Polyomavirus Infection

Chk1 and the Host Cell DNA Damage Response as a Potential Antiviral Target in BK Polyomavirus Infection

The human BK polyomavirus (BKPyV) is latent in the kidneys of most adults, but can be reactivated in immunosuppressed states, such as following renal transplantation. If left unchecked, BK polyomavirus nephropathy (PyVAN) and possible graft loss may result from viral destruction of tubular epithelia...

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Bibliographic Details
Main Authors: Lydia E. Hainley, Martina S. Hughson, Amithi Narendran, Ralph Smith, Justin Arthur, Alida Hayner-Buchan, David J. Conti, John M. Lehman, Thomas D. Friedrich
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
polyomavirus
BKPyV
BKV
DNA damage response
Chk1
antiviral
Online Access:https://www.mdpi.com/1999-4915/13/7/1353

Internet

https://www.mdpi.com/1999-4915/13/7/1353

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