Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality

Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality

Background/AimsInfectious and genetic factors are invoked, respectively in isolated biliary atresia (BA), or syndromic BA, with major extrahepatic anomalies. However, isolated BA is also associated with minor extrahepatic gut and cardiovascular anomalies and multiple susceptibility genes, suggesting...

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Main Authors: Juhoon So, Mylarappa Ningappa, Joseph Glessner, Jun Min, Chethan Ashokkumar, Sarangarajan Ranganathan, Brandon W. Higgs, Dong Li, Qing Sun, Lori Schmitt, Amy C. Biery, Steven Dobrowolski, Christine Trautz, Leah Fuhrman, Molly Christine Schwartz, Nikolai Thomas Klena, Joseph Fusco, Krishna Prasadan, Morayooluwa Adenuga, Nada Mohamed, Qi Yan, Wei Chen, William Horne, Anil Dhawan, Khalid Sharif, Deirdre Kelly, Robert H Squires, George K. Gittes, Hakon Hakonarson, Victor Morell, Cecilia Lo, Shankar Subramaniam, Donghun Shin, Rakesh Sindhi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
biliary atresia
liver transplantation
cilia
biliary morphogenesis
laterality
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.538701/full

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https://www.frontiersin.org/articles/10.3389/fphys.2020.538701/full

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