Di-n-butyl phthalate induces oversecretion of vascular endothelium-derived NAP-2 and promotes epithelial-mesenchymal transition of urothelial cells in newborn hypospadias rats

Di-n-butyl phthalate induces oversecretion of vascular endothelium-derived NAP-2 and promotes epithelial-mesenchymal transition of urothelial cells in newborn hypospadias rats

Di-n-butyl phthalate (DBP) is a plasticizer commonly used in industrial production and is present in our daily life. It has been confirmed that DBP causes genitourinary malformations, especially hypospadias. However, the research of hypospadias mainly focusses on the genital tubercle in previous stu...

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Bibliographic Details
Main Authors: Shan Hua, Fei Shi, Zhiwen Xie, Lei Wu, Mengqiao Dai, Yongqing Zhang, Xinyu Xu, Yiping Zhu, Juntao Jiang
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Hypospadias
Endothelial cells
Dibutyl phthalate
Epithelial-mesenchymal Transition
Neutrophil-activating peptide 2
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323003962

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http://www.sciencedirect.com/science/article/pii/S0147651323003962

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