A fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia.

A fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia.

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PspA and pneumolysin are two important vaccine candidates, able to elicit protection in different models of pneumococcal infection. The high immunogenic potential of PspA, combined with a possible adjuvant effect of pneumolysin derivatives (due to their ability to interact with TLR-4) could greatly...

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Bibliographic Details
Main Authors: Tanila Wood Dos Santos, Pedro Almeida Gonçalves, Dunia Rodriguez, José Aires Pereira, Carlos Augusto Real Martinez, Luciana C C Leite, Lucio F C Ferraz, Thiago Rojas Converso, Michelle Darrieux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0277304

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https://doi.org/10.1371/journal.pone.0277304

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