A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis

A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis

Glioblastoma (GBM) is a malignant brain tumor that grows quickly, spreads widely, and is resistant to treatment. Fibroblast growth factor receptor (FGFR)1 is a receptor tyrosine kinase that regulates cellular processes, including proliferation, survival, migration, and differentiation. FGFR1 was pre...

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Bibliographic Details
Main Authors: Yanran Bi, Ruiling Zheng, Jiahao Hu, Ruiqing Shi, Junfeng Shi, Yutao Wang, Peng Wang, Wenyi Jiang, Gyudong Kim, Zhiguo Liu, Xiaokun Li, Li Lin
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-01-01
Series:Genes and Diseases
Subjects:
Blood-brain barrier
EMT
FGFR1
FGFR1 inhibitor
Glioblastoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223000879

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http://www.sciencedirect.com/science/article/pii/S2352304223000879

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